We provide an ISI canceling circuit including a storing unit to store an ISI value associated with a received signal, an operator to generate an operator output signal by subtracting the ISI value from the received signal, and a comparator to manipulate the operator output signal responsive to an operating mode. We also provide a method for canceling ISI that includes storing a base voltage value of the received signal, sequentially storing ISI values of the received signal at time points when ISI is desired to be canceled, generating a difference between each of the stored ISI values and the stored base voltage value, and amplifying the subtracted signal to determine its logic state.