There is provided a hirulog-like peptide. Also provided is the treatment of vascular restenosis including the steps of administering an effective amount of a hirulog-like peptide in a pharmaceutically acceptable carrier whereby administration prevents vascular restenosis. A pharmaceutical composition including a hirulog-like peptide and a pharmaceutically acceptable carrier is also provided. A vector expressing a hirulog-like peptide is also provided. Also provided by the present invention is a method of treating a patient with vascular restenosis by introducing to the patient an amount of a sequence encoding a hirulog-like peptide sufficient to prevent vascular restenosis.