The present invention provides a 10,11-dihydrospiro[dibenzo[a,d][7]annulene -5,4'-imidazol]-5'(1'H)-one compound of formula I ##STR00001## Also provided are methods and compositions for the inhibition of .beta.-secretase (BACE) and the treatment of .beta.-amyloid deposits and neurofibrillary tangles.

 
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