A compound represented by the following general formula (I) or a salt
thereof, or a hydrate thereof or a solvate thereof having an inhibitory
action against plasminogen activator inhibitor-1 (PAI-1):
##STR00001##
wherein R.sup.1 represents a C.sub.6-10 aryl group; or a C.sub.6-10 aryl
group substituted with a group or groups selected from the group
consisting of a halogen atom, cyano group, nitro group, a C.sub.1-6 alkyl
group, a halogenated C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a
halogenated C.sub.1-6 alkoxy group and a C.sub.1-6 alkylsulfanyl group,
R.sup.2 represents a C.sub.6-10 aryl group; or a C.sub.6-10 aryl group
substituted with a group or groups selected from the group consisting of
a halogen atom, hydroxy group, a C.sub.1-6 alkyl group, a halogenated
C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a halogenated C.sub.1-6
alkoxy group, a C.sub.1-6 alkylsulfanyl group and phenyl group, X
represents a single bond or oxygen atom, Z represents a phenylene group
or a substituted phenylene group, m represents 0 or 1.