Disclosed herein is a biodegradable and bioactive glass-ceramic fabricated by mixing a slowly biodegradable glass-ceramic and a highly biodegradable glass-ceramic in a predetermined mixing ratio wherein the bioactivity is maintained to be constant, and the biodegradation rate is controlled by the mixing ratio. The biodegradable and bioactive glass-ceramic is fabricated from a composition consisting of calcium oxide (CaO), silica (SiO.sub.2), boron oxide (B.sub.2O.sub.3), magnesium oxide (MgO), calcium fluoride (CaF.sub.2) and phosphorus pentoxide (P.sub.2O.sub.5).