The present invention provides automated systems for the purification of
radioisotopes, the formulation of radiopharmaceuticals or both. In
preferred embodiments the radioisotopes are produced by a generator. In
further preferred embodiments the automated systems comprise replaceable
cassettes for easy replacement of the system's networks of tubing. Also
provided are replaceable cassettes and kits for use with the automated
systems of the invention.The invention further provides methods of using
an automated system to purify radioisotopes, formulate
radiopharmaceuticals or to do both in series.