The present invention provides the use of a compound of the Formula: (I) wherein R.sup.1 is C.sub.1-5 alkoxy, OCOC.sub.1-3Alkyl, O(CH.sub.2).sub.2O(CH.sub.2).sub.2O(CH.sub.2).sub.2OMe, O(CH.sub.2).sub.2O(CH.sub.2).sub.2O(CH.sub.2).sub.2OH or OH; R.sup.2 is H, (CH.sub.2).sub.nOH, OCH.sub.3, Hal or (II) or (III) R.sup.3 is H or (CH.sub.2).sub.nOH; and R.sup.4 is C.sub.1-6 alkyl, optionally substituted by one or more of Hal, OH, COCH.sub.3, NH.sub.2, NHCH.sub.3, NHMe, NMe.sub.2, OCOCH.sub.3, CO.sub.2H or esters or amides thereof where n is 1-5; and pharmaceutically acceptable salts thereof, in the manufacture of a medicament for use in modulating PKB activity. ##STR00001##