Compounds of formula (I), salts and solvates thereof are provided:
##STR00001##
wherein Ar is selected from phenyl, pyridyl and thienyl optionally
substituted with one or more groups Y; and each Y group is independently
selected from the group consisting of: halo, C.sub.1-4alkyl,
haloC.sub.1-4alkyl, C.sub.1-4alkoxy, cyano, C(O)C.sub.1-4alkyl,
NHSO.sub.2C.sub.1-4alkyl, NMeSO.sub.2C.sub.1-4alkyl, NHCOC.sub.1-4alkyl,
NMeCOC.sub.1-4alkyl, SOC.sub.1-4alkyl, SO.sub.2C.sub.1-4alkyl and
CO.sub.2C.sub.1-4alkyl, or two Y groups together form a cyclic group
--O(CH.sub.2)O--. Processes for preparation, and uses thereof in the
treatment of a disease or condition mediated by a reduction or imbalance
in glutamate receptor function, such as schizophrenia or cognition
impairment, are also disclosed.