There is provided a compound having a capsaicin receptor VR1 inhibitory
activity and useful as a therapeutic agent for various pains including
inflammatory pain and neurogenic pain, migraine, cluster headache,
bladder diseases including overactive bladder, and the like.A benzamide
derivative or a salt thereof wherein a benzene ring is attached to a D
ring (a monocyclic or bicyclic hydrocarbon ring or a monocyclic or
bicyclic heteroaromatic ring) through an amide bond, the benzene ring is
directly bonded to an E ring (a monocyclic or bicyclic hydrocarbon ring
or a monocyclic or bicyclic heteroaromatic ring), and the benzene ring is
further bonded to A (an amino moiety, a monocyclic or bicyclic
heterocycle) through L (a lower alkylene).