A method for synthesizing a polynucleotide is disclosed. The method
comprises providing a functionalized support comprising a triaryl methyl
linker bound to the solid support through a substitution on one of the
aryl groups, a nucleotide chain bound to the central methyl carbon of the
triaryl methyl group and a nucleoside with a reactive site hydroxyl. The
method further provides contacting that functionalized support with a
precursor having a hydroxyl protecting group and a phosphorous derivative
reactive group to produce internucleotide linkage. The resulting compound
is then treated to both remove the hydroxyl protecting group on the
precursor, and to oxidize the internucleotide bond.