A theft-prevention and tracking system and method for semi truck trailers or other vehicles. One or more status indicators, such as location, indication of unauthorized tampering, disconnection of the trailer from the truck, etc. communicate an alarm to a remote monitoring and dispatch center. A stolen vehicle can be remotely stopped at the command and control of the remote monitoring and dispatch center. Upon occurrence of a predetermined condition, such as stopping and blowing off the air from the brake system, the vehicle's brakes remain locked until entry of an authorization code or otherwise receiving authorization to proceed from the remote monitoring and dispatch center.