A gas-enhanced electrosurgical instrument includes a hand-held applicator and a portable actuator assembly. The hand-held applicator has a gas delivery member adapted to deliver pressurized ionizable gas to the proximity of an electrode located adjacent a distal end of the applicator. The portable actuator assembly is capable of holding a source of pressurized ionizable gas, such as a cylinder or cartridge, and includes at least one controller to control the delivery of the gas from the source to the hand-held applicator and to control the delivery of electrosurgical energy to the hand-held applicator.