[Problem] To provide a compound which may be used in treating diseases in
which a calcium sensing receptor (CaSR) is concerned, particularly
hyperparathyroidism. [Means for Resolution] It was found that novel
pyrrolidine derivatives which are characterized by the possession of
aminomethyl group substituted with arylalkyl group or the like, or salts
thereof, have excellent CaSR agonistic regulatory activity and also have
excellent selectivity with CYP2D6 inhibitory activity having a
possibility of causing drug interaction. Based on the above, these novel
pyrrolidine derivatives are useful as therapeutic agents for treating
diseases in which CaSR is concerned (hyperparathyroidism, renal
osteodystrophy, hypercalcemia and the like).