The present invention is related to a composition comprising
apolipoprotein L-l, the use of apolipoprotein L-l or a derivated
polypeptide for the diagnostic, the treatment and/or the prevention of
diseases induced in mammals by Trypanosoma. Another aspect is related to
a transgenic non-human mammal comprising a polynucleotide expressing the
apolipoprotein L-l or a derivated polypeptide and which is tolerant or
resistant to the Trypanosoma infection.