The present invention is further directed to compounds of the formulas:
(I) (II) (wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6,
R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.15, R.sup.16, R.sup.17,
R.sup.18, R.sup.19, R.sup.24 and R.sup.25 are as defined herein) which
are modulators of chemokine receptor activity and are useful in the
prevention or treatment of certain inflammatory and immunoregulatory
disorders and diseases, allergic diseases, atopic conditions including
allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as
autoimmune pathologies such as rheumatoid arthritis and atherosclerosis.
The invention is also directed to pharmaceutical compositions comprising
these compounds and the use of these compounds and compositions in the
prevention or treatment of such diseases in which chemokine receptors are
involved. ##STR00001##