The present invention discloses methods of modulating the activity of
Group I mGluRs using a defined class of benzamide compounds. In one
embodiment, methods of modulating the activity of mGluR1 are provided. In
another embodiment, methods of modulating the activity of mGluR5 are
provided. In still another embodiment, methods of simultaneously
modulating the activities of both mGluR1 and mGluR5 are provided. The
present invention also provides methods of treating diseases or disorders
which are mediated in full or in part by Group I mGluRs using one or more
compounds belonging to the defined class of benzamide compounds. The
present invention further provides methods of preventing diseases or
disorders which are mediated in full or in part by Group I mGluRs using
one or more compounds belonging to the defined class of compounds.
Diseases and disorders contemplated include, inter alia, diseases and
disorders of the central nervous system, the peripheral nervous system,
the gastrointestinal system, the circulatory system, skin, retina, brain,
heart, and lungs.