A system and method are provided for simplifying off-line quantification of ultrasound images by displaying a graphical user interface showing a real-time ultrasound image for enabling a user to freeze the real-time ultrasound image to display an image sequence capable of being modified and played back by the user. The graphical user interface displays graphs or curves providing data related to the ultrasound images. Each data point on the curves represents one ultrasound image of the ultrasound images. When the user selects a particular data point on a curve of a graph, the corresponding ultrasound image is displayed by the graphical user interface. The user can then select another data point on the same curve or another curve to display another corresponding ultrasound image. The two ultrasound image framescan then be compared. The system and method of the present invention further provide the ability for a user to select a region of interest within one of the displayed images to display parameters associated with the selected region of interest for the two ultrasound images.