The invention provides recombinant viruses comprising heterologous
envelope proteins capable of mediating entry of the recombinant viruses
into host cells. In one embodiment, a recombinant virus of the invention
is a member of the Paramyx-ovirzdae family (e.g., a respiratory syncytial
virus), and the heterologous envelope protein includes the ectodomain of
a baculovirus envelope protein (e.g., the GP64 protein). In some cases,
the heterologous envelope protein is provided in addition to homologous
envelope proteins) which may or may not be functional. The heterologous
protein can provide the recombinant virus with enhanced stability (e.g.,
at 4.degree. C., 22.degree. C., or 37.degree. C.), and allows production
of high-titer virus stocks. The heterologous protein can also impart
temperature sensitivity to the replication of the recombinant virus. In
addition, the recombinant virus can be designed to be infectious but
incapable of spreading between host cells by providing the heterologous
protein by complementation in trans. These features attenuate the
disease-causing potential of the recombinant virus, therefore increasing
its safety of use as vaccines.