Variable-density (VD), sequentially-interleaved sampling of k-space coupled with the acquisition of reference frames of data is carried out to improve spatiotemporal resolution, image quality, and signal-to-noise ratio (SNR) of dynamic images. In one example, ktSENSE is implemented with a non-static regularization image, such as that provided by RIGR or similar technique, to acquire and reconstruct dynamic images. The integration of ktSENSE and RIGR, for example, provides dynamic images with higher spatiotemporal resolution and lower image artifacts compared to dynamic images acquired and reconstructed using ktSENSE alone.