A formulation for treating or eliminating irritation and/or inflammation-reducing effect on endodermal tissue of the respiratory tract, the gastrointestinal tract, or both is disclosed. The formulation can include bisabolol or an extract containing bisabolol and actives found in ginger or extracted from ginger. The ratio of bisabolol and actives from ginger is adjusted such that the irritation and inflammation-reducing action of the bisabolol constituents and ginger constituents is increased synergistically.