A system for selective removal of metabolites from an aqueous broth including a bioreactor vessel containing at least one live culture producing at least one metabolite disposed within an aqueous broth, and a membrane module having a mixed matrix membrane suitable for selective removal of the at least one metabolite from the aqueous broth. The membrane is made of mixtures of hydrophobic zeolite and carbon on a porous substrate. In accordance with one particularly preferred embodiment of this invention, the membrane module is integral with the bioreactor vessel.