A method for isolating the bioactive component of the water-soluble
extract of Uncaria tomentosa known as C-MED-100.RTM., comprising (i)
precipitating the spray drying carrier from C-MED-100.RTM.; (ii) using
the resulting C-MED-100.RTM. to obtain a spotting mixture for thin layer
chromatography (TLC); (iii) spotting the C-MED-100.RTM. spotting mixture
on pre-run TLC plates and eluting the plates to obtain the fluorescing
band with R.sub.f=0.2-0.3; (iv) scraping off the R.sub.f=0.2-0.3 band,
eluting it in ammonia and freeze drying the eluted band to form a powder;
and (v) extracting the powder with methanol to remove solubilized silica
gel, concentrating the methanol solution and crystallizing the
concentrated solution to obtain the bioactive component. The isolated
bioactive component in vitro is a quinic acid analog, preferably quinic
acid lactone. By contrast, the isolated bioactive component in vivo is
quinic acid, whether as free acid or as a quinic acid salt, including
quinic acid ammonium salt. A pharmaceutical composition comprising a
pharmaceutically effective amount of the bioactive component and a
nontoxic inert carrier or diluent. The bioactive component may be used to
enhance immune competency, treat disorders associated with the immune
system, inhibit the inflammatory response, treat disorders associated
with the inflammatory response, enhance the anti-tumor response, and
treat disorders associated with the response to tumor formation and
growth, all in mammals.