The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, ##STR00001## or a pharmaceutically acceptable salt thereof, wherein R.sup.B, n, B, R.sup.C, R.sup.D, R.sup.E, A, and Z are described generally and in classes and subclasses below.The present invention also provides pharmaceutical compositions, methods and kits associated with Formula I, useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.