The invention consists of a hands-on, physically simulated human or animal body interior, containing physically simulated representations of all of the solid organs, hollow viscera, bladders, glands, major ducts, large and medium-sized blood vessels, muscle groups and interstitial tissues. The organs and vessels are life-sized and are composed of molded or sculpted open cell or closed cell foam rubber of varying density and load deformation, matching the physical properties of the specific biologic organs or tissues simulated. The organs, tissues and vessels may be treated with pigments, sealants and/or hardening agents to reflect the contours, appearances, densities, textures, elasticity, and deformability of normal or pathologically-altered internal organs and tissues. Organs contain molded vascular channels, reversibly attached to the larger blood vessels of the simulator. The model has a pressurized, watertight, simulated vascular system, monitored by electronic sensors.