A method, system, apparatus, and article of manufacture for performing cacheline polling utilizing store and reserve and load when reservation lost instructions is disclosed. In one embodiment a method is provided which comprises storing a buffer flag busy indicator data value within a first cacheable memory location and setting a load/store operation reservation on said first cacheable memory location via a store and reserve instruction. In the described embodiment, a data value stored within the first cacheable memory location is accessed via a conditional load instruction in response to a determination that the load/store operation reservation on the first cacheable memory location has been reset. Conversely, execution of the conditional load instruction is stalled in response to a determination that the load/store operation reservation on the first cacheable memory location has not been reset.