Compounds that competitively inhibit binding of CSP to S. mutans histidine
kinase are provided. The compounds are preferably a peptide or an
antibody, and are preferably a derivative of [SEQ ID NO:2], a fragment of
[SEQ ID NO:2] or a derivative of a fragment of [SEQ ID NO:2]. Methods of
making these compounds and their use for inhibiting the growth of S.
mutans, for inhibiting dental caries, and for improving dental health are
also disclosed.