This invention relates to compounds, compositions, and methods useful for
modulating platelet derived growth factor (PDGF) and/or platelet derived
growth factor receptor (PDGFr) gene expression using short interfering
nucleic acid (siNA) molecules. This invention also relates to compounds,
compositions, and methods useful for modulating the expression and
activity of other genes involved in pathways of platelet derived growth
factor (PDGF) and/or platelet derived growth factor receptor (PDGFr) gene
expression and/or activity by RNA interference (RNAi) using small nucleic
acid molecules. In particular, the instant invention features small
nucleic acid molecules, such as short interfering nucleic acid (siNA),
short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA
(miRNA), and short hairpin RNA (shRNA) molecules and methods used to
modulate the expression of platelet derived growth factor (PDGF) and/or
platelet derived growth factor receptor (PDGFr) genes, such as PDGF
and/or PDGFr.