The invention provides isolated nucleic acids molecules, designated GL50
nucleic acid molecules, which encode novel GL50 polypeptides. The
invention also provides antisense nucleic acid molecules, recombinant
expression vectors containing GL50 nucleic acid molecules, host cells
into which the expression vectors have been introduced, and nonhuman
transgenic animals in which a GL50 gene has been introduced or disrupted.
The invention still further provides isolated GL50 polypeptides, fusion
proteins, antigenic peptides and anti-GL50 antibodies. Diagnostic,
screening, and therapeutic methods utilizing compositions of the
invention are also provided.