Medical devices, such as stents, having a surface, a coating layer
comprising a polymer disposed on at least a portion of the surface, and a
composition comprising a biologically active material injected into or
under the coating layer at one or more locations in the coating layer to
form at least one pocket containing a biologically active material are
disclosed. The composition may be injected using a nanometer- or
micrometer-sized needle. Methods for making such medical devices are also
disclosed. Using this method, a precise amount of the biologically active
material may be disposed accurately and efficiently on the medical device
at predefined locations.