An exemplary system for measuring operational life of a computer mouse wheel is disclosed. The system includes a computer (10), a control card (11), a stepper motor servo controller (12), a stepper motor (13), a vertical servo axle (14), and a measurement platform (15). The vertical servo axle is structured and arranged for maintaining contacting with the computer mouse wheel (16). The computer is configured for sending an instruction for controlling operations of measuring the operational life of the computer mouse wheel, and includes a file module (20), a setting module (21), and a performing module (22). The control card is configured in the computer. A related method is also disclosed.