A multi-density skin marker for medical imaging exams is provided. The skin marker contains a multi-density imaging body. In one embodiment, a multi-density skin marker includes a marker substrate and a multi-density imaging body supported by the marker substrate. The multi-density imaging body comprises a first portion having a first radiographic density and a second portion having a second radiographic density. The two radiographic densities differ, such that a radiographic image of the multi-density skin marker comprises a plurality of shades.