A multi-channel remote keyless entry (RKE) transponder having dynamically re-configurable input channel selection, channel disable, settable sensitivity for each channel, wake-up filter timing parameters, automatic gain control hold, internal tuning capacitor selection for each channel's antenna, minimum modulation depth requirement for input signal and bi-directional talk-back. Programmable minimum modulation depth requirement reduces false wake-up of the RKE transponder. An antenna for each channel of the RKE transponder may be tuned with internal tuning capacitors for improved range and receiver sensitivity. The internal tuning capacitor parameters may be stored in a configuration register. Gain of the channel may be fixed while the antenna is tuned. The antennas may be de-queued for talk-back to a base station for low frequency bi-directional communications. An external control device may dynamically read from and write to the configuration registers via a serial communications interface.