An assay system and methods are described where patient samples containing genomic DNA are analyzed for the presence of known genetic polymorphisms using a universal reporter strategy. In a preferred embodiment, the amplified DNA is localized at test sites in an array of sites on a microchip followed by a series of hybridization reactions that screen for the presence of a single mutation from among a number of mutations, and allow the identification of specific mutations. In addition to universal reporters, the assay may use blockers and discriminators for screening and identification of known polymorphisms.

 
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< Multiplexed active biologic array

> Capturing sequences adjacent to type-IIS restriction sites for genomic library mapping

> Mesoporous permeation layers for use on active electronic matrix devices

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