Systems and methods provide scene-based non-uniformity correction for infrared images, in accordance with one or more embodiments. For example in one embodiment, a method of processing infrared images includes storing a template frame comprising a first plurality of pixel data of an infrared image; receiving an input frame comprising a second plurality of pixel data of an infrared image; determining frame-to-frame motion between at least some of the first and second plurality of pixel data; warping the template frame based on the determining of the frame-to-frame motion; comparing the first plurality of pixel data to the second plurality of pixel data to determine irradiance differences based on the determining; propagating pixel offset information for scene based non uniformity correction terms, based on the determining of the frame-to-frame motion, for at least some of the scene based non uniformity correction terms to other ones of the scene based non uniformity correction terms; updating the scene based non uniformity correction terms based on the comparing and the propagating; applying the scene based non uniformity correction terms to the second plurality of pixel data to reduce fixed pattern noise; and providing an output infrared image after the applying.