The invention provides a waterproof and dustproof structure of a joint portion of an industrial robot which is inexpensive and does not adversely affect a motion performance of a robot. Accordingly, in a manipulator type robot which has a cable passing hole provided in a part of an outer periphery of a manipulator, and is provided with a cable wired to an inner side and an outer side of the manipulator through the cable passing hole, a mold guide surrounding an outer periphery of one or a plurality of conducting wire passing through an inner portion is provided near the cable passing hole, an inner side of the mold guide is mold treated by a resin filling, and a sealing material is provided in an outer side of the mold guide.