A method for stabilizing retinoic acid is provided. The method includes a
step of mixing retinoic acid with a hydrophobic polymer/hydrophilic
polymer adduct in the presence of an oxygen containing atmosphere to form
a retinoic acid containing composition. The hydrophobic
polymer/hydrophilic polymer adduct comprises a
poly(vinylpyrrolidone/alkylene) polymer and a polymer comprising
repeating carboxylic acid groups, hydroxyl groups, or a mixture of
carboxylic acid groups and hydroxyl groups. A retinoic acid containing
composition and a method of using a retinoic acid containing composition
are provided.