A system for capturing and neutralizing HAP's (hazardous air pollutants) and VOC's (volatile organic compounds) at the source point by providing a closed loop remediation system which utilizes an air collection, treatment and control module containing a predetermined size bay of multiple interchangeable mini-biofilter cartridges that function to consume the pollutant and recirculate remediated air back to the source point of the pollutant. The system includes establishing a closed loop air system at a work station which generates and emits VOC's, capturing the VOC's in the air stream flow and transporting them directly into an adjacent biofilter module which contains selected microorganisms in mini-cartridges which biodegrade said VOC's and recirculates remediated air back to the source point of the pollutant. The cartridges may be contained in modules in single and/or multiple widths and heights and in conjunction with various work stations, cabinets, receptacles, and tables.