Mast cell degranulation inhibitors having a carboxyl group have not been
developed as external preparations due to the low transdermal
permeability thereof. By formulating external preparations thereof, side
effects on the internal organs by oral administration can be avoided.
Some of the mast cell degranulation inhibitors show drastically inferior
photostability, which is also one cause of suppressed development of the
drug as an external preparation.
The present invention aims at improving the transdermal permeability and
photostability of mast cell degranulation inhibitors by forming a salt of
the mast cell degranulation inhibitor with an organic amine.
Consequently, an external preparation of a mast cell degranulation
inhibitor can be provided and the photostability of the mast cell
degranulation inhibitor itself, and a preparation containing same can be
improved.