The target is to provide PDE IV inhibitors which have a highly potent
anti-asthmatic and/or COPD-prophylactic/therapeutic profile with
unexpectedly excellent safety. A compound of the formula (1):
##STR00001## wherein A is phenyl, pyridyl, 1-oxypyridyl, or thienyl,
which may be unsubstituted or optionally substituted with one or more
members selected from the group consisting of hydroxyl, halogen, cyano,
nitro, lower alkyl, lower alkoxy, lower alkylcarbonyloxy, amino,
carboxyl, lower alkoxycarbonyl, carboxy-lower alkylene, lower
alkoxycarbonyl-lower alkylene, lower alkylsulfonyl, lower
alkylsulfonylamino, and ureido; R.sup.1 is a group selected from the
group consisting of hydrogen, hydroxyl, halogen, cyano, nitro, lower
alkoxy, amino, carboxyl, and lower alkoxycarbonyl; R.sup.2 is hydrogen or
lower alkyl; and m is an integer of 1 to 3; or a pharmaceutically
acceptable salt thereof, possesses highly excellent PDE IV-specific
inhibitory actions and is useful as an anti-asthmatic drug and/or a
prophylactic/therapeutic drug for COPD with high safety.