Methods, computer program products, and systems are described that include monitoring at least one attribute of an individual during an artificial sensory experience while the individual is under the influence of a bioactive agent, identifying at least one characteristic of the artificial sensory experience that is proximate to a desired change in the at least one attribute of the individual, and/or modifying at least one of the artificial sensory experience or the bioactive agent at least partly based on the identifying at least one characteristic of the artificial sensory experience that is proximate to the desired change in the at least one attribute of the individual.