In a method for the operation of a medical diagnosis apparatus in an examination, a region of an examination subject to be imaged is placed in an imaging volume of the diagnosis apparatus, a first dataset of the region of interest is registered with a first set of operating parameters of the diagnosis apparatus, and the first set of operating parameters and the first dataset are stored. In a follow-up examination wherein the region of interest is again placed in the imaging volume, a follow-up dataset of the region of interest is registered with the apparatus operated with the stored, first set of operating parameters and the follow-up dataset is stored.