An imaging diagnosis system for generation of a three-dimensional image data set of an examination subject has an image acquisition unit that acquires three-dimensional raw data of the examination subject, an image reconstruction unit that generates a three-dimensional image data set from the three-dimensional raw data, an image processing unit that detects anatomical structures of the examination subject from the image data set, and a position determination unit that determines the position of an anomaly (identified by a diagnostician) in the anatomical structures of the examination subject in the image data set and generates position data for the image acquisition unit. The image acquisition unit acquires perfusion-sensitive raw data with the aid of the position data of the detected anomaly, which perfusion-sensitive raw data contain perfusion information of the identified anomaly.