The present invention relates to new piperidinyl- or
piperazinyl-substituted-3,4-dihydro-2H-1-benzopyran derivatives having
formula (I) wherein X is N or CH; Y is NR.sub.2 CH.sub.2, CH.sub.2
NR.sub.2, NR.sub.2 CO, CONR.sub.2 or NR.sub.2 SO.sub.2 wherein R.sub.2 is
H or C.sub.1 -C.sub.6 alkyl; R.sub.1 is H, C.sub.1 -C.sub.6 alkyl or
C.sub.3 -C.sub.6 cycloalkyl; R.sub.3 is C.sub.1 -C.sub.6 alkyl, C.sub.3
-C.sub.6 cycloalkyl or (CH.sub.2).sub.n -aryl, wherein aryl is phenyl or a
heteroaromatic ring containing one or two heteroatoms selected from N, O
and S and which may be mono- or di-substituted; n is 0-4; R.sub.9 is
C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, OCF.sub.3,
OCHF.sub.2, OCH.sub.2 F, halogen, CONR.sub.6 R.sub.7, CN, CF.sub.3, OH,
C.sub.1 -C.sub.6 alkoxy, NR.sub.6 R.sub.7, SO.sub.3 CH.sub.3, SO.sub.3
CF.sub.3, SO.sub.2 NR.sub.6 R.sub.7, an unsubstituted or substituted
heterocyclic or heteroaromatic ring containing one or two heteroatoms
selected from N and O, wherein the substituent(s) is(are) C.sub.1 -C.sub.6
alkyl; or COR.sub.8 ; wherein R.sub.6, R.sub.7 and R.sub.8 are as defined
above, as (R)-enantiomers, (S)-enantiomers or racemates in the form of a
free base or pharmaceutically acceptable salts or solvates thereof, a
process for their preparation, pharmaceutical compositions containing said
therapeutically active compounds and to the use of said active compounds
in therapy.
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