Using separate synthesizers in a radio frequency (RF) device can facilitate avoiding interference. Specifically, a first synthesizer can be programmed to generate a first output frequency signal having an Frf frequency. A second synthesizer can be programmed to generate a second output frequency signal having an Fif frequency. Notably, a sum of the Frf and Fif frequencies equals an Fchannel frequency of the RF device. Thus, any RF channel can be received (or transmitted) with a plurality of VCO frequencies for each of the two synthesizers. A table of Frf/Fif combinations can be used to determine an Frf/Fif combination that avoids a known interfering source. Alternatively, Frf/Fif combinations can be randomly chosen until an interfering source is avoided.