An information handling system includes a wireless device and interference suppression apparatus that adapts to the different interference problems experienced by the wireless device when the system changes from one operating mode or state to another. The interference suppression apparatus includes a controller that instructs an adaptive filter with respect to the appropriate filter characteristics to employ to suppress interference when the system is operating in a first mode. When the system changes to a second mode of operation, the interference suppression apparatus updates the filter characteristics to filter characteristics which are appropriate for suppressing interference associated with the second mode of operation.