The invention is directed towards a method and transmission attempt determining device for adjusting the targeted number of transmission attempts in uplink communications between mobile stations and a cell in a wireless network handled by a cell handling device. According to the invention measurement data (RC) of radio conditions and service requirement data (SR) of the uplinks for mobile stations are obtained (36, 38, 40). Based on this data a determination (42) is made if the targeted number of transmission attempts should be adjusted. If a change should be made (42) an increase or a decrease is then determined (44) and the targeted number of transmission attempts are adjusted in the selected direction (46).