A stethoscope protective device is for easily and hygienically covering the head and at least a portion of the connector tube of a stethoscope. The device can be quickly applied to the stethoscope while eliminating or minimizing the need for contact by a patient of the head and connector tube during examination. In a single-handed operation, the stethoscope head and connector tube can be readily slipped into and secured within the protective device. The device is constructed at least in part of a material that is acoustically transmissive and provides a barrier for reducing the transmission of microorganisms.