A review workstation for facilitating interpretation of a medical image by a user is described. The review workstation comprises a display device displaying the medical image to the user, and an input device receiving a graphical identification of a region of interest (ROI) in the medical image that is interesting to the user. Responsive to the identification of the ROI, a content-based image comparison is performed between the ROI and a resource database, the resource database comprising a collection of resource images previously analyzed by human interpreters and textual information associated with those previous analyses. The content-based image comparison comprises identifying a subset of the resource images similar to the ROI with respect to a preselected set of computed features. The display device subsequently displays to the user at least one of the identified subset of resource images and its associated textual information simultaneously with the ROI.