A processing system with reconfigurable instruction extensions includes a processor, programmable logic, a register file, and a load/store module. The processor executes a computer program comprising a set of computational instructions and at least one instruction extension. The programmable logic receives configuration information to configure the programmable logic for the instruction extension and executes the instruction extension. The register file is coupled to the programmable logic and stores data. The load/store module transfers the data directly between the register file and a system memory.