The invention provides for methods of detecting and treating diseased tissue, particularly in skin diseases or disorders, such as psoriasis, scleroderma, eczema or atopic dermatitis tissue. The method involves administrating a composition comprising an antibody specific to the diseased tissue to a patient. After administration, the antibody in the composition binds to the exposed cell surface antigen (epitope) and allows the detection and/or disrupts the growth of the diseased tissue. In addition, this invention provides methods of treating psoriasis, scleroderma, eczema or atopic dermatitis by eliciting an immune response in an individual against an antigen which is only exposed to antibody detection in tissues affected by these disorders